国产加替沙星胶囊治疗急性细菌性感染227例临床分析

Treatment of 227 Cases Acute Bacterial Infection with Indigenous Gatifloxacin capsule

目的 评价国产加替沙星胶囊治疗急性细菌性感染的有效性和安全性。方法 采用多中心随机双盲双模拟对照方法 ,观察治疗 2 2 7例呼吸系统和泌尿系统急性细菌性感染。观察组( 113例 )口服加替沙星胶囊 2 0 0mg ,对照组 ( 114例 )口服左氧氟沙星胶囊 2 0 0mg ,两组均每天服用 2次 ,疗程为 7～ 14天。结果 观察组与对照组的临床痊愈率分别为 83 .19%和 73 .68% ;总有效率分别为 94.69%和 92 .11% ;细菌清除率分别为 10 0 %和 99% ;不良反应发生率分别为 7.96%和 14 .91%。两组有效率、细菌清除率和不良反应发生率比较 ,差异均无显著性 (P >0 .0 5 )。结论 国产加替沙星胶囊是一种广谱、安全。

Objective To estimate the efficacy and tolerability of indigenous gatifloxacin capsule on acute bacterial infection.Methods In this randomized,double-blind,multicenter,comparable clinical trial,227 cases respiratory tract infections and urinary tract infections were divided into two groups.113 patients took orally gatifloxacin capsule 200mg and 114 patients took orally levofloxacin capsule 200mg twice daily for 7～14 days.Results Clinical cure rates and total effective rates were 83.19% and 94.69% in the gatifloxacin group,73.68% and 92.11% in the levofloxacin group;the corresponding bacterial eradication rates were 100% and 99% respectively;the clinical adverse reaction rates were 7.96% and 14.91%.No significant difference in the above figures between the two groups.Conclusion Indigenous Gatifloxacin capsule is a broad-spectrum,safe,effective antibiotic.