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高迁移率族蛋白-1的结构与细胞外功能 被引量：2

Structure and function of extracellular HMGB-1
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摘要 高迁移率族蛋白 1(HMGB 1)是一种核蛋白 ,属于HMG蛋白超家族 ,由 2 15个氨基酸组成 ,相对分子质量为 2 5 0 0 0 ,在哺乳动物细胞核内普遍存在。新近发现HMGB 1可由单核 /巨噬细胞等通过非经典的、囊介导的分泌通路而分泌至细胞外。细胞外的HMGB 1是一个重要炎症因子 ,参与多种疾病尤其是类风湿性关节炎、脓毒症、急性肺损伤等的发病机制 ,甚至可导致动物死亡。对HMGB 1细胞外机制与功能的进一步研究 。 HMGB-1, an ubiquitously expressed 25-KD nucleoprotein among mammals, belongs to the HMG family. Recent studies have identified that HMGB-1 is secreted by activated monocytes/macrophages via a non-classical ,vesicle-mediated secretory pathway. Extracellular HMGB-1 is an important proinflammatory cytokine. It participates in the pathogenesis of many diseases such as rheumatoid arthritis, sepsis , acute lung injury, and even leads animals death. Further studies of the mechanism and function of extracellular HMGB-1 may provide a novel strategy for the diagnosis and treatment of these diseases.
作者 姜南艳 于文彬 苏明权
机构地区 第四军医大学西京医院检验科
出处 《医学研究生学报》 CAS 2004年第11期1012-1014,1018,共4页 Journal of Medical Postgraduates
关键词 高迁移率族蛋白-1 结构-功能研究 细胞外 High mobility group box chromosomal protein 1 Structure-function analysis Extracellular
分类号 R392.1 [医药卫生—免疫学]
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参考文献21

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二级参考文献12

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医学研究生学报
2004年 第11期

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