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卡维地洛防治心肌血管损伤的细胞分子学研究进展 被引量：2

The molecular cytologic research progress of Carvedilol on myocardial and vascular injury
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摘要 卡维地洛 (Carvedilol)作为第三代 β受体阻断药 ,具有非选择性 β受体α1受体阻滞作用 ,临床主要用于治疗原发性高血压、稳定性心绞痛、轻 中度慢性心力衰竭。除此以外 ,还具有较强的抗氧化损伤作用 ,抑制氧自由基对血管内皮细胞及平滑肌细胞的损伤 ,抑制血管平滑肌细胞的增生和迁移 ,抑制血管损伤后新生内膜的形成等 。 Carvedilol is a non-selective beta-blocker with additional blockade of alpha_(1)-adrenoceptors.It has been applied in the treatment of hypertention、stable angina pectoris、chronic heart failure.In addition,Carvedilol exerts antioxidant and anti-apoptosis effects,it can inhibits vascular smooth muscle cell proliferation、migration and neointimal formation following vascular injury.The article makes a review on the molecular cytologic mechanism of Carvedilol in these aspects.
作者 王璟 江时森
机构地区 第二军医大学南京临床医学院南京军区南京总医院心血管内科
出处 《医学研究生学报》 CAS 2004年第11期1023-1026,共4页 Journal of Medical Postgraduates
关键词 卡维地洛 抗氧化 凋亡 抑制增生 Carvedilol Antioxidant Apoptosis Proliferation
分类号 R972.4 [医药卫生—药品]
  • 相关文献

参考文献15

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二级参考文献23

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共引文献16

同被引文献44

  • 1何志良.从中医治未病思想论高血压及其并发症的防治[J].实用医技杂志,2008,15(14):1881-1882. 被引量：18
  • 2段艳杰,张辉,郑永刚.原发性高血压患者血清SOD和MDA及NO检测的临床意义[J].实用医技杂志,2006,13(11):1856-1857. 被引量：8
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引证文献2

二级引证文献14

医学研究生学报
2004年 第11期

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