病毒性肝炎患者血清总胆汁酸测定及临床意义

Clinical significance of detection of serum total bile acids in patients with viral hepatitis

目的 探讨血清总胆汁酸(TBA)测定在病毒性肝炎诊断中的价值.方法 用酶比色法对213例病毒性肝炎患者及30例正常对照进行测定,并对结果进行统计处理.结果 正常对照组TBA为11.11±8.64μmol/L.病毒性肝炎组急性期(或活动期)的TBA与正常对照组相比差异均具有显著(P<0.01),各组中急性期(或活动)与恢复期相比差异亦具有显著性(P<0.01);在恢复期组中,慢性肝炎中度及肝硬变组与急性黄疸期比较差异具有显著性(P<0.05).结论 血清TBA的含量与肝病的病变相关,对肝炎的诊断、预后判断及辅助鉴别诊断具有一定的价值.

Objective To study the value of serum total bile acids (TBA) in patients with viral hepatitis-Methods The sreum TBA in specimens collected from 213 patients with viral hepatitis and from 50 normal controls were detected by enzymatic colorimetry and analysed statistically. Results The serum TBA level in acute (or active) period of hepatitis, chronic hepatitis (mild degree), chronic hepatitis (moderate) and cirrhosis were 138.1±109. 6, 39. 4±29. 4, 103. 8±91. 1, 132. 2±103. 6 μmol/L respectively. Compared with that of the control group (11. 1±8. 6μmol/L), the differences between various groups were very significant (P<0. 01), so was between the acute (or active) period and recovery period of hepatitis (P<0. 01). The TBA contents in acute hepatitis were statistically higher than those of chronic hepatitis (moderate) (P<0. 05) and cirrhosis (P<0. 05). Conclusion The serum TBA content is related to viral hepatitis, which might be helpful in clinical diagnosis and judgement of prognosis in patients with hepatitis.