α-2b干扰素联合苦参碱治疗慢性乙型病毒性肝炎临床疗效观察

Clinical study on the treatment for chronic hepatitis B with α-2b interferon combined with matrine

目的 观察α 2b干扰素联合苦参碱治疗慢性乙型病毒性肝炎的临床疗效及对乙肝病毒标志物的影响。方法 选择深圳市东湖医院 1998- 0 8～ 2 0 0 4 - 0 2门诊及住院的慢性乙型肝炎患者 4 6 0例 ,随机分成治疗组2 95例 ,给予 10 %葡萄糖 2 5 0mL +苦参碱 15 0mg每日 1次静滴 (3个月 ) ,给予α 2b干扰素 5 0 0万单位 ,每日 1次肌肉注射 (10d) ,以后为隔日 1次 (6个月 )。对照组 16 5例 ,单用α 2b干扰素治疗 ,剂量疗程与治疗组相同。两组同时给予 10 %葡萄糖 15 0mL +强力宁 10 0mL每日 1次静脉滴注 3个月。同时观察两组患者的肝功能 ,乙肝病毒标志物的变化。结果 两组患者血清ALT及AST在治疗过程的复常率差异无显著性 (P >0 0 5 ) ,HbeAg阴转率分别是 5 7 0 %和 38 8% (P <0 0 1) ,HBVDNA阴转率是 5 9 3%和 4 2 4 % (P <0 0 1) ,抗Hbe阳转率是5 0 8%和 33 9% (P <0 0 1)。结论 α 2b干扰素联合苦参碱是治疗慢性乙型病毒性肝炎较有效的方法。

Objective To observe the clinical effect of α-2b interferon and matrine on treatment of chronic hepatitis B and the influence of HBV markers.Methods 460 patients with chronic hepatitis B were divided into two groups randomly.295 cases in the treated group were treated with 10% glucose 250ml and matrine 150mg,iv,Qd×3M,and α-2b interferon 5 million unit,im,Qd×10D,then Qod×6M.165 cases in the control group were treated with α-2b interferon only by the same dosage and course.Both groups were treated with 10% glucose 150ml and potenlin 100ml,iv,Qd×3M and observe the changes of the liver function and the HBV markers.Results There was no significant deviation of the ALT and AST recovery rate in both groups (P>0.05).The HBeAg-turned-to-negative rate was 57% in the treated group and 38.8% in the control group.The HBVDNA-turned-to-negative rate was 59.3% in the treated group and 42.4% in the control group (P<0.01).The anti-HBe-turned-to-positive rate was 50.8% in the treated group and 33.9% in the control group (P<0.01).Conclusion The combination of α-2b interferon and matrine is an effective method in the treatment of chronic hepatitis B.