急性冠状动脉综合征致病危险因素分析

Predisposing Factors to Acute Coronary Syndrome of Clinical Study

目的 :探讨急性冠状动脉综合征中致病危险因素的变化情况及其意义。方法 :对 10 7例行冠脉造影的急性冠脉综合征(急性心肌梗死及不稳定型心绞痛 )与其它类型冠心病的血管阻塞积分进行计算 ,将其血糖、血脂等进行比较。结果 :急性冠脉综合征患者中有高血压、冠心病、糖尿病家族史和 (或 )伴高血压、糖尿病者 4 8例 (6 2 .3% ) ,其C反应蛋白 (CRP)、血糖、血脂紊乱情况均较其它型冠心病更为明显。在急性心肌梗死与冠心病组中 ,血管阻塞积分与年龄明显相关。在急性心肌梗死组中 ,吸烟者的发病年龄与HDL明显低于不吸烟者 ,而红细胞压积则明显高于不吸烟者。结论 :急性冠脉综合征的发生与遗传、吸烟、血糖。

Objective: To investigate clinical predisposing factors to acute coronary syndrome (ACS).Methods: The coronary vessel obstructive scores on coronary angiography were counted in patients with ACS including acute myocardial infarction (AMI) and unstable angina pectoris (UAP), and other types of coronary heart disease (CHD). Risk factors for CHD were also compared between patients with or without ACS. Results: Patients with ACS had family history of hypertension, CHD, diabetes mellitus, and/or were associated with hypertension and diabetes mellitus in 48 cases (62.3%), whose blood glucose and disturbance of serum lipid level was markedly higher than those of other CHD. In groups of AMI and CHD, the coronary artery obstructive scores had a tendency of correlating increasingly with ages. In the group of AMI with smoking, the ages of onset and HDL were lower than those of non-smoking, while their hemotocrits were higher significantly. Conclusion:Abnormal risk factors of inheritance, smoking, diabetes, dyslipidemia, and CRP elevation maybe involved in the development of ACS.