氟铁龙与5-氟脲嘧啶在结直肠癌辅助化疗中的疗效比较

Comparison of the Adjuvant Chemotherapy Effects of Furtulon and 5-FU on Colorectal Cancer

目的 :总结氟铁龙 (Furtulon ,FTL)与 5 -氟脲嘧啶 (5 -FU)在结直肠癌术后辅助化疗的比较。方法 :回顾分析 4 6例接受Furtulon为主治疗 6个周期的结直肠癌病例 (A组 ) ,并与同期用 5 -氟脲嘧啶为主治疗 6个周期的 33例结直肠癌病例 (B组 )进行比较。结果 :随访 3～ 4年 ,A组的复发率为 4 .3%转移率为 10 .9% ,B组的复发率为 15 .8%转移率为 2 3.7% ,两组病例的复发率及转移率无统计学差异 ,而A组 (FTL组 )较B组 (5 -FU组 )毒副作用轻 ,有显著差异。结论 :Furtulon在结肠、直肠癌辅助化疗中疗效较好 ,使用方便 。

Objective: To compares effects of Furtulon (5'-DFUR) and 5-FU as the postoperative treatments of colorectal cancers. Methods: A retrospective analysis was made on 79 cases of colorectal cancers from Jan. 2000 to Aug. 2001. 46 patients who had taken Furtulon for 6 cycles were in group A and 33 patients who had taken 5-Fu for 6 cycles were in group B. Clinical results were analyzed according to the two groups of patients. Results: With following up for 3 to 4 years, the rate of recurrence is 4.3% and the rate of metastasis was 10.9% in-group A. The response rates in-group B was 15.8% and 23.7%. Statistical analysis showed that there were no significant differerence in the rate of recurrence and metastasis between the two groups. However the side effects in-group A are not so severe as group B and which was significant difference when compares with the other group. Conclusion: Furtulon has fewer side effects. It is an effective regimen for patients with colorectal cancers.