胰岛素对高血压大鼠脑缺血再灌注期脑梗死体积的影响

THE EFFECT OF INSULIN ON CEREBRAL INFART AFTER REPERFUSION IN HYPERTENSION RAT

目的:观察胰岛素对脑缺血再灌注损伤的治疗作用。方法:制备肾血管性高血压大鼠(RHR),用线栓法复制大脑中动脉阻塞(MCAO),造成缺血6h再灌注18h,术后立即及6h后即时使用胰岛素,测定脑梗死体积的变化。结果:与对照组比较,实验组脑梗死体积及其占全大脑体积百分比、两半球体积差值均显著减小(P<0.05)。结论:胰岛素能减轻脑缺血再灌注损伤,早期用药效果更好。

Objective: To study the effect of insulin on reperfusion injur y after cerebral ischemia. Methods: The renovascular hypertension rats (RHR) with MCAO as described by Zea Longa for 6 hours and reperfusion for 18 hours .The infarct volume and the margine of the both hem isphere were measured at 24 hours after MCAO following treated immediately and 6 hours with insulin after reperfusion. Results: The infarct volume and the margine of the both hemisphere were significantly lower in the test groups compared with the controlled groups (P < 0.05). Conclusion: Insulin may reduce reperfusi on injury used as early as possible.