老年男性骨密度与脂质过氧化相关性研究

Correlation between bone mineral content and lipid peroxidation in male elderly

对９８例男性老年人的骨密度、血清超氧化物歧化酶（ＳＯＤ）、过氧化脂质（ＬＰＯ）、丙二醛（ＭＤＡ）、谷光甘肽（ＧＳＨ）进行测定，旨在研究老年人骨密度值变化与衰老的关系。结果：老年人ＢＭＤ、ＳＯＤ、ＧＳＨ随年龄增长逐渐减少，ＢＭＤ与ＳＯＤ、ＧＳＨ水平呈正相关，与ＬＰＯ、ＭＤＡ水平呈负相关。表明老年人骨密度与其衰老生化指标呈显著相关。老年人骨密度的丢失可作为衰老的重要指标之一。

98 healthy males aged over 60 were recruited for determination of bone mineral content, serum superoxide dismutase (SOD),lipid peroxide (LPO), MDA and glutathione peroxidase (GSH) in order to find the possible relationship between senescence and these markers. The results showed that BMD,SOD and GSH decreased with the increase of age. BMD was positively relative to SOD and GSH,but negatively relative to LPO and MDA. Loss of BMD might be a criterion for diagnosis of senescence.