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survivin基因表达与妇科肿瘤关系的研究进展 被引量：4

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摘要 凋亡抑制基因survivin发现于1997年,是凋亡抑制蛋白家族(IAPs)中相对分子质量最小的成员,与效应细胞蛋白酶受体1(EPR-1)关系密切,其结构独特,组织分布有明显的特征性.在100多种肿瘤特异性表达基因中,其表达特异性居第三,是肿瘤发生、发展中的枢纽基因,并与肿瘤放、化疗中的耐药密切相关.本文着重综述survivin基因的表达与妇科肿瘤关系的研究进展.
作者 邓凯贤 钟玲
机构地区 重庆医科大学附属第二医院妇产科
出处 《中华妇产科杂志》 CAS CSCD 北大核心 2004年第8期566-568,共3页 Chinese Journal of Obstetrics and Gynecology
关键词 妇科肿瘤 SURVIVIN基因 特异性表达 研究进展 受体1 凋亡抑制蛋白 凋亡抑制基因 发现 蛋白酶 组织分布
分类号 R737.3 [医药卫生—肿瘤] R735 [医药卫生—肿瘤]
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参考文献21

  • 1Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene,survivin, expressed in cancer and lymphoma. Nat Med,1997 ,3 :917-921.
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同被引文献29

  • 1田兴松,王新刚,周文红,孙靖中.乳腺癌细胞中p16、p21、cyclinD1的表达及临床意义[J].山东大学学报（医学版）,2005,43(6):532-535. 被引量：10
  • 2张剑,魏先锋,张志远,罗伍根.鼻内镜手术前后鼻腔分泌液中血小板源性生长因子和肿瘤坏死因子α及透明质酸的变化[J].中华耳鼻咽喉头颈外科杂志,2005,40(7):498-502. 被引量：2
  • 3李学昌,闵家新,蒋力,姚珂,张国强.非小细胞肺癌组织中Survivin、p16基因的表达及关系[J].第三军医大学学报,2006,28(22):2289-2292. 被引量：7
  • 4Vogelsten B, Kinzler KW. The muhistep nature of cancer [ J]. Trends Gentel, 1993,9 : 138 - 148.
  • 5Ambrosini G, Adida C, Altieri DC. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma [ J ]. Nat Med, 1997, 3(8) :917 -921.
  • 6Fukuda S, Pelus LM. Survivin, a cancer target with an emerging role in normal adult tissues [ J ]. Mol Cancer Ther, 2006, 5 ( 5 ) : 1087 - 1098.
  • 7Zhao L, Lobo S, Dong X. Erf4p and Ert2p form endoplasmic retieu- lumassociated complex involved in the plasm membrane localization of yeast, ras proteins [ J J Biol Chem, 2002, 277 (51 ) : 49352 - 49359.
  • 8Franssani MA, Cusmai A, Piccoli C. Manumycin inhibits famesyl- transferaseand induces apoptosis of drug-resistant interleukin 6-producingmyeloma cels [ J] . Br J Haematol, 2002, 188 ( 1 ) : 157 - 165.
  • 9Ambrosini G, Adida C, Altieri DC. A novel anti - apoptosis gene, survivin, expressed in cancerand lymphoma [ J ]. Nat Med, 1997,3 ( 8 ) : 917-921.
  • 10Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression [J]. EMBO J .2003.22(11) :2729-2740.

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中华妇产科杂志
2004年 第8期

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