东莨菪碱、乌头注射液辅助吗啡治疗顽固性晚期癌痛的临床探讨

The Clinical Study of Morphine with Adjuvant Chinese Traditional Medicine for Treatment of Refractory Cancer Pain

目的 :应用东莨菪碱、乌头注射液辅助吗啡治疗 8例顽固性癌痛患者 ,比较治疗前后的镇痛效果 ,行为、休息状况以及吗啡用量。方法 :选择 8例经吗啡反复治疗且效果欠佳的顽固性晚期癌痛患者 ,应用东莨菪碱、乌头注射液、氟哌利多持续静脉泵注治疗 ,并按患者需要给予吗啡 ,观察治疗前后的镇痛效果、行为评分 ,休息状况以及吗啡用量。结果 :8例患者经中药辅助吗啡治疗后镇痛效果、行为评分、休息评分均明显优于单纯吗啡治疗(P <0 .0 5 ) ;同时 ,治疗后吗啡用量比治疗前少 (P <0 .0 5 )。结论 :东莨菪碱、乌头注射辅助吗啡治疗顽固性晚期癌痛具有较好效果。

Objective:To Compare the analgesic effect,performance and rest status,the dose of morphine used before and aftert.the adjuvant treatment of scopolamine and aconitic injection.Methods:8 advanced cancer patients with refractory pain after repeated morphine treatment were given continuous intravenous pumping of the mixed liquid of scopolamine,aconitic injection and droperidol.Morphine was also given as needed.The analgesic effect,performance and rest status as well as the used dose of morphine were observed.Results:For the 8 patients receiving adjuvant Chinese traditional medicine,the analgesic effect,performance and rest scores were significantly better than using morphine alone (P<0.05) and the dose of morphine was lower (P<0.05).Conclusion:Morphine combined with adjuvant scopolamine and aconitic injection offered satisfied effect for refractory pain of advanced cancer patients.