奥氮平与氟哌啶醇对精神分裂症病人生活质量影响的双盲对照研究

ADOUBLE BLIND COMPARING STUDY BETWEEN THE EFFECTS OF HALOPERIDOL AND OLANZAPINE ON THE QUALITY OF LIFE OF THE PATIENTS WITH SCHIZOPHRENIA

目的 探讨氟哌啶醇和奥氮平对精神分裂症患者生活质量的影响。方法 采用双盲对照研究。对 1 2 0例精神分裂症患者随机分为两组 ,分别给予氟哌啶醇和奥氮平治疗 6个月。用阳性症状与阴性症状量表 (PANSS)评定精神症状 ,用副反应量表 (TESS)评定不良反应。用生活质量综合评定问卷(GQOLI)分析病人生活质量。结果 奥氮平和氟哌啶醇相比 ,对精神分裂症阳性症状的改善相似 ,对阴性症状的改善明显占优 ,PANSS两组间评分差异无显著性 ;不良反应明显减少。奥氮平组GQOLI总分 ,躯体功能、心理功能、社会功能维度及其各因子与氟哌啶醇组相比分值升高 (P <0 .0 1 )。

Objective To explore the impact of haloperidol and olanzapine on quality of life in patients with schizophrenia.Methods Adopting double blinded contral study, 120 schizophrenia patients were randomly divided into haloperidol group or olanzapine group,which was treated with haloperidol or olanzapine respectively for six months.ts mental symptom were assessed in all subjects with Positive and Negative Symptom Scale (PANSS), adverse effects with Treatment Emergency Symptom Scale (TESS), the quality of life with General Quality of Life Inventory(GQOLI).Results Compared with haloperidol group olanzapine group was similar effects on positive symptoms, was significantly superior effects on negative symptoms, there was no significant different in the score of PANSS; adverse effects were significant fewer.The total score of GQOLI, physical function、mental health、social function and its every factor in olanzapine group were higher than haloperidol group(P<0.01).Conclusion The quality of life of schizophrenic patients treated by olanzapine were better than that of haloperidol.