肝、胰联合移植一例报告

A case report of combined liver pancreas transplantation

目的探讨肝、胰联合移植治疗终末期肝病合并胰岛素依赖型糖尿病的效果。方法为1例慢性乙型病毒性肝炎、肝硬化、原发性肝细胞癌、胰岛素依赖型糖尿病患者施行同期原位肝、异位胰联合移植,术后监测移植肝脏及胰腺的功能。结果术后移植肝、胰功能良好,完全停用胰岛素,无相关外科并发症,术后曾发生急性排斥反应1次,经甲泼尼龙冲击逆转。患者现已存活6个月,恢复正常生活和工作。结论肝、胰联合移植可用于肝病合并胰岛素依赖型糖尿病的治疗。

Objective To probe the indication, technique and effect of combined liver pancreas transplantation. Methods Donor organs were harvested by the technique of total abdominal evisceration. Simultaneous orthotopic liver and heterotopic pancreas duodenum transplantation was performed in one patient diagnosed as having chronic hepatitis B, hepatocirrhosis, hepatic cellular cancer, and insulin dependent diabetes. Liver and pancreas graft function was monitored after transplantation. Results The recipient recovered with excellent allograft function, and insulin independence was achieved without any surgical complication. Conclusion End stage liver disease with concomitant insulin dependent diabetes is the indication for combined liver pancreas transplantation.