超声造影诊断移植肾急性肾小管坏死的实验研究

Diagnosis of acute tubular necrosis in renal allograft with contrast ultrasound: an experimental study

目的 探讨应用超声造影时间 -强度曲线 (TIC)诊断移植肾急性肾小管坏死的可行性。方法 建立犬移植肾急性肾小管坏死模型 ,采用自身对照法 ,进行经静脉超声造影及声学定量分析TIC各参数 ,同时跟踪病理活检。结果 急性肾小管坏死发生后 ,曲线峰值前移 ,TIC参数除峰值密度 (PI)值外 ,灌注曲线下面积(AUC)、峰值减半时间、造影剂平均通过时间、AUC皮质与皮髓质交界部比率均明显降低。结论 超声造影结合TIC定量分析 ,可客观反映移植肾急性肾小管坏死血流灌注变化 。

Objective To investigate the diagnostic feasibility of acute tubular necrosis(ATN) in renal allograft using time intensity curves by intravenous contrast ultrasound.Methods The canine models of acute tubular necrosis in renal allograft were established,and examined subsequently with intravenous contrast ultrasound using auto control,and also the parameters of time intensity curves were analyzed,tracking the renal biopsies simultaniously.Results After ATN occured, the curve peak was ante displaced.And parameters of TIC (except peak intensity,PI),area under the curve(AUC),half time of descent(HT),mean transit time(MTT),the ratio of AUC were decreased dramatically.Conclusions Contrast ultrasound combined with TIC quantitative analysis could reflect the variation of blood perfusion objectively,and it is a potential new method for diagnosis of ATN in renal allograft.