不同中医治法对大鼠肝癌作用的比较

Comparison of the Functions of Different Chinese Medical Therapies to Liver Cancer in Rats

采用ＤＥＮ成功诱发大鼠肝癌，分别观察抑癌扶正行气活血、清热解毒、扶正行气活血、健脾扶正等４种常用治法对肝癌大鼠生存率、肝脏病理及Ｎｒａｓ、Ｈｒａｓ、Ｐ５３等基因转录水平的作用。结果表明：依据４种治法所拟定的处方均能不同程度地提高大鼠生存率；对大鼠肝癌有一定的抑制作用，对肝脏某些基因的转录水平有一定的调控作用。总体疗效以抑癌扶正行气活血法最佳。

In rat liver cancer successfully induced by DEN,the functions of four common therapeutic methods of inhibiting cancer by supporting the anti_pathogenic ability,circulating qi and activating blood,of clearing away heat and eliminating toxin,of supporting the anti_pathogenic ability by circulating qi and activating blood,and of strengthening the spleen and supoorting the anti_pathogenic ability to the survival rate of the rats with liver cancer,pathology of the liver and gene transcription of N_ras,H_ras,and P 53 were observed respectively.The results showed that the formulas designed upon these four therapeutic methods could enhance the survival rate of rats in varying degrees and have certain inhibiting function to liver cancer in rats and certain regulating and controlling ability in transcription of some gene in liver .Generally,the method of inhibiting cancer by supporting the anti_pathogenic ability,circulating qi and activating blood is best in total therapeutic effect.