克塞灵单次给药对家兔降纤及溶栓作用

Effects of Catholen by Once IV Administration on Reducing Fibrinogen and Dissolving Thombus in Rabbits

目的:观察克塞灵(Cath)单次ⅳ给药对家免血浆纤维蛋白原含量的影响及溶栓作用。方法:单次家兔ⅳCath后,分别于24、48、72h从家免心脏取血测定血浆纤维蛋白原含量;Cath的溶栓作用观察,首先制备血栓并称重,将制备好的血栓植入同一麻醉家兔动脉—静脉(A—V)、动脉—动脉(A—A)半体外人造血液循环通路中。结果:Cath0.25 u·kg^124h、Cath0.5 u·kg^124、48h可显著降低血浆纤维蛋白原含量(P<0.05)。Cath0.25、0.5 u·kg^1单次给药可使血栓重量减轻,同对照组比较有显著性差异(P<0.01),0.25、0.5 u·kg^1组间溶栓作用比较无显著性差异(P>0.05),同一家免A-V、A-A之间溶栓作用比较无显著性差异(P>0.05)。结论:Cath0.25、0.5 u·kg^1单次给药可降低家兔血浆纤维蛋白原含量并有溶栓作用。

Aim:To study the effect of Catholen(Cath)by once iv administratin on reducing the content of fibrinogen and dissolving in rabbits . Methods: The blood samples were elected from the heart of rabbits at 24,48 and 72 h respectively after Oath was administered into the vein of rabbits'ear, then the content of fibrinogen was measured. To observe the effects of dissolving thombus,the thombus was artificial made and weighted firstly, then the prepared thombus was transplanted into the man-made passage of blood circulation system of the experimental rabbits, the dissolving effects were observed through the artery-vein(A-V) and artery - artery( A - A) administration way in the same rabbits. Results: The resultsshowed that 0. 25u·kg-1 Cath given at 24 h, 0. 5 u·kg-1 Cath given at 24 and 48 h could reduce the content of fibrinogen significantly(P<0. 05) .Gompared with the controls, there was a significant difference between the experimental group and controls(P<0. 01) . In disolving thrombi, there was not a significant difference between the 0.25 and 0. 5u · kg-1 group(P>0. 05)and there was not a significant difference between A-V, A-A experimenteal method in dissolving thrombolysis in the same rabbits(P> 0.05). Conclusion: The results suggest that 0.25, 0. 5 u ·kg-1Cath once iv administration could reduce fibrinogen and dissolving thrombus effectively.