慢性病毒性肝炎肠道菌群变化及与血中内毒素的关系

目的:观察慢性病毒性肝炎的肠道菌群及血中内毒素的情况,并探讨两者的关系。方法:检测40例慢性肝炎患者及20例健康人的新鲜粪便中的双歧杆菌和大肠杆菌。同时取外周静脉血,定量检测内毒素。结果:在慢性肝炎时,双歧杆菌有明显减少(P<0.05),95％的B/E值低于正常,外周血中内毒素显著升高(P<0.001),大肠杆菌无显著性差异(P>0.05)。并发现双歧杆菌与内毒素有相关性(r=-0.3845,PV<0.05),B/E与内毒素也有相关性(r=-0.5795,P<0.001),但大肠杆菌与内毒素无相关性(r=-0.2529,P>0.10)。结论:在慢性肝炎时肠道中有菌群失调,且与外周血中的内毒素升高有相关性。

To study microfloral in intestine, endotoxin in peripheral blood among chronic hepatitis patients and their rela - tionship. Methods: Hifidobacteria and E. Coli were cultured in fresh fecal specimens of 40 chrinic hepatitis patients and 20 healthy adults . At same time, the endotoxin concentration in blood was determined by quantitative method. Result: The nurnibers of Bifidoberia in chronichepatitis petients were significantly less than those in healthy adults (P<0.05), B/E was smaller than normal in 95% patients. Endotoxin concentrations in patients were significantly higher than those in controls(P<0.001 ) .The numbers of E. coli were not significantly different in two groups (P>0.05) . The decrease of Hifidobacteria was correlated with elevated endotoxin concentration (r=-0.3845, P<0.05). B/E was correlated with endotoxin concentration(r =-0.5795, P<0. 001). But, E. coli was not correlated with endotoxin(r =-0.2529, P>0. 10).Conclusion: there is intestinal dysbacteriosis in chronic hepatitis pat ients, and it was correlated with the elevatedendotoxin concentration.