磺脲类合并二甲双胍继发失效的2型糖尿病加用拜糖平的疗效观察

Efficacy of acarbose in the treatment of type 2 diabetes m ellitus patients with secondary failure tocom bination of sulfonylurea and metformin

目的 观察磺脲类合并二甲双胍继发失效的２ 型糖尿病加用拜糖平的疗效。方法 将５０ 例磺脲类与双胍类联合治疗继发失效的２ 型糖尿病人按非等量随机分组的原则分为拜糖平组（３０例） 和安慰剂组（２０ 例） ，治疗３ 个月，比较治疗。结果 拜糖平组患者的空腹和餐后１ 、２ 小时血糖明显下降，有效率为４８ ．３ ％ ；安慰剂组治疗前后血糖维持不变，仅１ 例有效。结论 加用拜糖平可作为磺脲类与双胍类药物联合应用失效后的治疗方法之一。

Objective Studying the efficacy of acarbose in the treatment of type 2 diabetes mellituspatients with secondary failure to com bination of sulfonylurea and metformin . Methods 50 type 2 diabetesmellitus patients with secondary failure to combination of sulfonylurea and metformin were divided randomlyinto 2 groups :acarbose group ( n = 30) and placebo group ( n = 20) ;3 monthslater ,the efficacy of acarbosewas compared . Results The levels of fasting and 1 and 2 hour postprandial blood glucose decreasedsignificantlyin acarbose group with an effective rate of48 .3 % ,butrem ained unchanged exceptonein placebogroup . Conclusion Acarbose is one ofthe choicesin type 2 diabetes mellitus patients with secondary failure tocombination of sulfonylurea and metformin .