N,N—二取代二硫代草酰胺与二元胺反应的研究

Studies of the Reactions Between N,N'-Disubstituted Thioxamide and Diamines

本文研究了N,N′-二取代二硫代草酰胺与二元胺(乙二胺、1,3-丙二胺、反-1,2-环己二胺)在二甲基亚砜中的反应。用IR、~1H NMR和四圆衍射法测定了产物的结构。实验结果表明,反应存在着两种方式,一种是二元胺的两个氨基反应在同一个硫代酰基的碳原子上(如乙二胺、1,3-丙二胺)。而另一种由于立体的影响,反应在两个相邻硫代酰基的两个碳原子上(如反-1,2-环己二胺)。

The reactions between N, N'-disubstituted thioxamide and diamines (1, 2-diaminoethane, 1, 3-diaminopropane, trans-1, 2-diaminocyclohexane) are studied in this paper. Various products are obtained from different diamines. The structures of the products are confirmed by IR, ~1HNMR and X-ray diffraction study. There exist two kinds of reactions, one is that amino groups of diamines react with the same carbon atom of N, N'-disubstituted thioxamides, the other is that two amino groups react with different carbon of the thioxamides.