Cu(Ⅱ)-氨基酸-核苷酸三元配合物的合成和表征

Synthesis and Characterization of Ternary Complexes Containing Cu(Ⅱ), Amino Acid and Nucleotide

合成和表征Ｎａ２〔Ｃｕ（Ｌ－Ａｌａ）２（５＇－ＧＭＰ）〕·２Ｈ２Ｏ、Ｎａ２〔Ｃｕ（Ｌ－Ａｌａ）２（５＇－ＩＭＰ）〕·６Ｈ２Ｏ、Ｎａ２〔Ｃｕ（Ｌ－Ｈｉｓ）（５＇－ＧＭＰ）Ｃｌ２＾２·２Ｈ２Ｏ和Ｎａ２〔Ｃｕ（Ｌ－Ｈｉｓ）（５＇－ＩＭＰ）Ｃｌ２〕·Ｈ２Ｏ四个新的三元配合物，其中两个Ｌ－Ａｌａ分子通过羧基Ｏ和α－氨基Ｎ与Ｃｕ（Ⅱ）成反式配位，一个Ｌ－Ｈｉｓ分子通过羧基Ｏ和咪唑环上的Ｎ与Ｃｕ（Ⅱ）配位；

The study on metal-aminoacid-nucleotide ternary complexes may provide a model for the more complicated metal-protein-nucleic acid interaction. The ternary complexes containing Cu(Ⅱ), amino acid (L-Ala and L-His) and nucleotide(5'-GMP and 5'-IMP) were first synthesized and characterized. In these complexes the O atom at carboxylate group and the N atom at α-amino group of two L-Ala coordinate with Cu(Ⅱ), the O atom at carboxylate group and the N atom at the imidazol ring of a L-His coordinate with Cu(Ⅱ), the N(7) atom of purine ring of 5'-GMP or 5'-IMP coordinates with Cu(Ⅱ) too. There is interaction between phosphate group of 5'-GMP with L-Ala or L-His, but no the interaction in 5'-IMP ternary complexes. The C(6)=O of purine for 5'-GMP or 5'-IMP may be coordinating with Cu(Ⅱ) or forming hydrogen bond.