摘要
乙酰水扬酸(阿斯匹林)具有较高的药用价值,对它的性质有较多的研究,如在水中的稳定性和水解等。乙酰水扬酸有一个脂键和一个羰基。脂键易水解,水解后药用价值虽未降低,但有很大的副作用,因而研究抑制乙酰水扬酸水解是很有意义的。本文用RD—Ⅲ型热导式自动量热计研究了在十六烷基三甲基溴化胺(CTAB)胶束溶液中乙酰水扬酸的水解反应热动力学。
The alkaline hydrolysis of acetyl salicylic acid has been studied in CTAB micellar system with the method of thermokinetics for the pseudo-first-order reactions. The second-order-rate constants of this reaction at 30 and 35℃ in the absence of CTAB are 0.0394 and 0.0628 L·mol^(-1)·s^(-1), respectively. The rates of this reaction in CTAB micellar system at 30 and 35℃ have decreased with the increase of CTAB concerntration at the considerable values of [OH^-]. This reaction has been found to be inhibited by CTAB micelles.
出处
《化学研究与应用》
CAS
CSCD
1993年第1期50-54,共5页
Chemical Research and Application
基金
国家自然科学基金
关键词
乙酰水扬酸
CTAB胶束
水解反应
Alkaline hydrolysis
Acetyl salicylic acid
CTAB miecllar solution
Thermokinetics
