丁螺环酮与丙咪嗪治疗广泛性焦虑症的对照研究

A comparative study of buspirone and imipramine in the treatment of generalized anxiety disorder

目的 比较丁螺环酮与丙咪嗪治疗广泛性焦虑症的疗效与不良反应。方法 将 70例符合CCMD 3诊断标准的广泛性焦虑症患者 ,随机分为两组 ,分别应用丁螺环酮或丙咪嗪治疗 6周 ,采用焦虑自评量表(SAS)、Hamilton焦虑量表 (HAMA)和不良反应量表 (TESS)进行疗效及不良反应评定。结果 丁螺环酮与丙咪嗪对广泛性焦虑症的治疗均有显著疗效 ,但疗效差异无显著性 ,(χ2 =0 .12 9,P >0 .0 5 ) ,丁螺环酮的不良反应明显低于丙咪嗪 (t=4 .73,P <0 .0 1)。结论 丁螺环酮治疗广泛性焦虑症安全有效 。

Objective To compare the efficacy and side effects of buspirone and imipramine in the treatment of patients with generalized anxiety disorder.Methods A total of 70 patients who met with the criteria of CCMD-3 for generalized anxiety disorder were randomly assigned to buspirone and imipramine for the treatment of 6 weeks.Efficacy and side effects were assessed by SAS,HAMA,and TESS.Results Both drugs had marked efficacy in treating generalized anxiety disorders,however,there was no significant difference on efficacy between the two drugs (χ 2=0.129,P>0.05).Buspirone had fewer side effects than imipramine(t=4.73,P<0.01).Conclusion Buspirone is a safe and efficient drug for the treatment of generalized anxiety disorder.