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胃癌化疗的多药耐药逆转机制新进展 被引量：4

Recent advances in reversion mechanism of multiple drug resistances to chemotherapy of gastric carcinoma
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作者 朱金水 朱励
机构地区 上海交通大学附属第六人民医院消化科
出处 《武警医学》 CAS 2004年第9期643-646,共4页 Medical Journal of the Chinese People's Armed Police Force
基金 上海市自然科学基金资助项目(02zb14072)
关键词 胃癌细胞 癌化 多药耐药逆转 化疗药物 白及 新进展 P-糖蛋白 转机 机制 产生
分类号 R735.2 [医药卫生—肿瘤] R979.1 [医药卫生—药品]
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参考文献12

  • 1Hajek P,Villani G,Attardi G et al.Rate- limiting step preceding cytochrome c release in cells primed for fas- mediated apoptosis in revealed by analvsis of cellular mosaicism of respiratory changes. J Biol Chem,2001,276:606- 615
  • 2Canitrot Y, Bichat F, Cole SP et al . Multidrug resistance genes (MRP)and MDR1 expression in small cell lung cancer xenogratts: relationship with response to chemotherapy.Cancer Lett, 1998,130:133 - 141
  • 3Singh KK, Russell J, Sigala B et al . Mitochondrial DNA determines the cellular response to cancer therapeutic agents..Oncogene, 1999,18:6 641 -6 646
  • 4Mitsunaga Y, Takanaga H, Matsuo H et al Effect of bioflavonoids on vincristine transport across blood - brain barrier. Eur J Pharmacol, 2000,359:193 - 201
  • 5Keppler D, Leier I, Jedlitschky G Transport of glutathione conjugates and glucuronides by the multidrug resistance proteins MRP1 and MRP2. Biol Chem, 1997,378:787- 791
  • 6Rappa G, Finch RA, Sartorelli AC et al New insights into the biology and pharmacology of the multidrug resistance protein (MRP) from gene knockout models. Biochem Pharmacol, 1999,58: 557 - 562
  • 7Endo K, Maehara Y, Kusumoto T et al Expression of multidrug- resistance- associated protein (MRP) and chemosensitivity in human gastric cancer Int J Cancer,1996,68: 372 - 377
  • 8KuWano M, Toh S, Uchiumi T et al . Multidrug resistanceassociated protein subfamily transporters and drug resistance Anticancer Drug Res, 1999,14:123 - 131
  • 9Nakamura T, Oka M,Aizawa K et al Direct interaction between a quinoline derivative, Ms - 209, and multidrug resistance protein (MRP) in human gastric cancer cells. Biochem Biophys Res Commun, 1999,255: 618 - 624
  • 10Bash- Babula J,Toppmeyer D, Labassi M et al A phase I/pilot study of sequential doxorubicin/vinorelbine: Effects on p53 and mocrotubule- associated protein 4 Clinical Cancer Res,2002,8:1057- 1064

二级参考文献6

共引文献28

同被引文献31

引证文献4

二级引证文献14

武警医学
2004年 第9期

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