血清超敏C-反应蛋白水平与冠心病的相关性研究

The relationship between serum high-sensitivity C-reactive protein level and severity of coronary heart disease

目的 探讨血清超敏C 反应蛋白 (hs CRP)与冠心病的相关性及其临床意义。方法 选择冠状动脉造影确诊冠心病的 84例患者 ,按疾病类型分组 ,其中稳定性心绞痛组 3 2例 ,不稳定性心绞痛组 40例 ,急性心肌梗死组 12例 ,正常对照组 5 0例。应用散射速率比浊法测定血清hs CRP浓度。结果 hs CRP水平在对照组、稳定性心绞痛组、不稳定性心绞痛组、急性心肌梗死组依次增高。稳定性心绞痛组hs CRP水平显著高于正常对照组 (P <0 .0 1)。不稳定性心绞痛组、急性心肌梗死组hs CRP水平又显著高于对照组和稳定性心绞痛组 (P <0 .0 1)。结论 冠心病患者血清hs CRP水平升高 ,是冠心病的一项独立危险因子 ;冠心病与冠状动脉硬化斑块内的炎症反应有关 ;hs CRP水平对冠心病的病变程度具有预测价值。

Objective To explore the relationship and significance between serum high-sensitivity C-reactive protein(hs-CRP) level and coronary heart disease(CHD). Methods 84 patients diagnosed with CHD by coronary angiography ,32 patients with stable angina,40 patients with unstable angina,12 patients with acute myocardial infarction,50 healthy persons as normal control group.Their serum hs-CRP levels were determined by scatter velocity turbidimethy.Results The hs-CRP level were increased progressively.in normal control group, stable angina group unstable angina group and acute myocardial infarction group the hs-CRP level in the stable angina group were significantly higher than that of the normal control group(P<0.01). the hs-CRP levels in the unstable angina group and the acute myocardial infarction group were significantly higher than that of normal control group and stable angina group(P<0.01).Conclusions The patients with coronary heart disease have higher levels of serum hs-CRP and it is another independend risk factor of coronary heart disease.The coronary heart disease is related to inflammation of atherosclerosis plaque in coronary artery.hs-CRP may be the predictor factor of patients condition in coronary heart disease.