乙肝病毒携带产妇HBIG应用及不同喂养方式对婴儿的影响

The application of HBIG to parturients women carring HBsAg and the effect of dif ferent feeding way to infants

目的 :探讨乙肝病毒携带产妇的母乳喂养问题。方法 :将 13 4例HBsAg阳性产妇分为 2组 ,HBIG组(A组 ) 66例 ,于孕 2 8、3 2、3 6周分别注射HBIG 2 0 0IU ,非HBIG组 (B组 ) 68例不用药。分别检测孕妇外周血、初乳和婴儿 0、6个月外周血中乙肝两对半和HBV DNA。结果 :HBIG组与非HBIG组初乳中HBsAg阳性率差别无显著性 ,初乳中不论HBsAg阳性或阴性 ,婴儿行母乳喂养或人工喂养 6月龄HBsAb阳性率差异无显著性。结论 :HBsAg携带孕妇婴儿进行母乳喂养和人工喂养 6月龄婴儿外周血HBsAb阳性率差异无显著性。

Objective To explore the breast feed ing of parturients women carring HBsAg. Methods From March 2001 to March 2003, 134 parturients women carring HBsAg were divided into two groups. Group A (n=66), which HBIG 200 IU was given monthly in late pregnancy; Group B (n=68), which abtained onl y common antenatal care. The pregnant women's vein blood, colostrums and the v ein blood of infants (age=0, 6-month old) underwent an examination of HBV immu nological markers and HBV-DNA. Results The HBsAg positive rate in colostrums of group A and that of group B had no significant difference. For 6 months infants, the HBsAb positive rate of infant blood had no significant difference between breast - feeding and artificial-feeding no matter positive or negative the HBsAg in colo s trums. Conclusion As the infants of pregnant women carring HBsAg were 6 months old, the HBsAb positive rate of infant blood had no significant difference betw een breast-feeding and artificial-feeding.