胃粘膜不同病变与内源性亚硝基化合物合成关系的初步研究

A STUDY ON THE RELATIONSHIP BET WEEN THE DIFFERENT CHANGES OF MUCOUS MEMBRANE OF STOMACH AND THE ENDOGENOUS FORMATION OF N-NITROSO COMPOUNDS

本文首次初步地研究我国山东省胃癌高发区居民不同胃粘膜病变者体内亚硝化反应。在日常膳食条件下,胃粘膜不典型增生组24小时尿亚硝基脯氨酸排出量为11.64μg (1.71-47.9),明显高于胃粘膜正常或浅表性胃炎组(6.30μg)和慢性萎缩性胃炎组(5.18μg)。不典型增生组尿总亚硝基氨基酸排出量为51.88μg,比正常或淡表性胃炎组高近一倍(29.5μg),比慢性萎缩性胃炎组高两倍(14.59μg)。该地区居民尿中硝酸盐、亚硝酸盐的排出量都较高。

A research work on the endogenous nitrosation was done in high-risk area for gastric cancer in Shandong province. Under the ordinary, 24 hours urinary excretion of Nitrosoproline was 11.64 (1.74-47.90) μg in the Dysplasia group. It was significantly higher than normal or superficial gastritis (SG) grouP (6.03 μg) and chronic atrophic gastritis (CAG) group (5.18 μg). The urinary excretion of total nitrosamino acids was 51.88μg in dysplasia group which was twice as high as in normal or SG group (29.50 μg ) and three times as high as in CAG group (14.59 μg) . The excretions of nitrate, nitrite of residents in this area were higher than those in other areas.