前列腺素E_1脂微球与米力农在治疗老年肺心病心力衰竭中对比研究

Comparison study on the therapeutic effect of lipo PGE_1 and miliron for elder patients with heart failure of cor pulmonale

目的 :比较前列腺素E1 脂微球(LipoPGE1凯时)与米力农对老年肺源性心脏病心力衰竭的疗效。方法 :对86例老年肺源性心脏病心力衰竭,随机分为LipoPGE1 组和米力农组,予以LipoPGE110μg/d静脉推注 ,疗程14天 ,米力农2.5mg/d静脉推注及7.5mg/d静脉滴注,疗程7天观察效果。分析老年肺源性心脏病心力衰竭治疗前后肺动脉压力(PASP)、氧分压(PaO2) 二氧化碳分压(PaCO2)、心脏指数(CI)、全血比粘度、全血还原粘度、血浆比粘度、红细胞压积、血沉方程K值变化 ,结果 :LipoPGE1 组PASP由治疗前 (6.56±0.63)mmHg显著下降至 (4.44±0.52)mmHg(P<0.01),米力农组PASP由治疗前(6.51±0.63)mmHg显著下降至(4.41±0.33)mmHg(P<0.01),LipoPGE1组和米力农组均能使CI显著增加(P<0.05),且LipoPGE1 组治疗后全血比粘度、全血还原粘度、红细胞压积显著降低(P<0.01) ,PaO2 明显上升(P<0.01)结论 :LipoPGE1 组和米力农组对老年肺源性心脏病心力衰竭疗效显著 ,均有明显降低PASP,提高CI作用。

Objective:To compare the therapeutic effect of lipo PGE 1 and miliron for treating elder patients with heart failure of cor pulˉmonale.Methods:86elder patients with heart failure of cor pulmonale were divided into two groups at randomly.The lipo PGE 1 group was given lipo PGE 1 10ug by intravenous injection once daily for14days,the miliron group was given miliron2.5mg by intravenous injection,then7.5mg by intravenous drip once daily for7days.The changes of pulmonary artery shrink pressure(PASP)、PaO 2 、PaCO 2 、cardiac index(CI),whole blood contrast viscosity,whole blood reduction viscosity,blood plasma contrast viscosity and RBC cumulation and Kvalue in ESR equation were measured before and after treatment.Results:PASP was significantly decreased from(6.51±0.63)mmHg before treatment to(4.44±0.52)mmHg after treatment in the lipo PGE 1 group(P<0.01)and from(6.51±0.63)mmHg before treatment to(4.41±0.33)mmHg after treatment in the miliron group(P<0.01).CI in both groups was obviously increased(P<0.05).Whole blood contrast viscosity,whole blood reduction viscosity and RBC cumulation in the lipo PGE1group were obviously decreased after treatment(P<0.01),but PaO 2 was significantly increased(P<0.01).Conclusion:The therapeutic effect of lipo PGE 1 group and miliron group for elder patients with heart failure of cor pulmonale is significant,both lipo PGE 1 and miliron have a obvious role in reducing PASP and improving CI.