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副流感病毒的分子生物学性状及其疫苗的研究进展 被引量：5

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摘要 副流感病毒是一类不分节段的单股负链RNA病毒 ,可引起所有年龄组人群的呼吸道感染 ,尤其可引起婴幼儿及儿童严重呼吸道疾病。本文基于副流感病毒的分子生物学性状就其近年来疫苗的研究进展作一综述。
作者 陈行昀 高琦 许楠 李梅 李晓眠
机构地区 天津医科大学微生物教研室
出处 《国外医学（病毒学分册）》 2004年第5期154-158,共5页 Foreign Medical Sciences(Section of Virology)
关键词 副流感病毒 分子生物学 研究进展 疫苗 严重 呼吸道感染 人群 负链RNA病毒
分类号 R373 [医药卫生—病原生物学]
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参考文献19

  • 1Alexander C, Schmidt, Daniel R. Wenzke et al. Mucosal Immunization of Rhesus Monkeys against Respiratory Syncytial Virus Subgroups A and B and Human Parainfluenza Virus Type 3 by Using a Live cDNA-Derived Vaccine Based on a Host Range-Attenuated Bovine Pa
  • 2Pennathur S, Haller AA, MacPhail M et al. Evaluation of attenuation, immunogenicity and efficacy of a bovine parainfluenza virus type 3 (PIV-3) vaccine and a recombinant chimeric bovine/human PIV-3 vaccine vector in rhesus monkeys. J Gen Virol, 2003, 84:3
  • 3Alexamder C. Schmidt, Josephine M. McAuliffe, Brian R. Murphy et al. Recombinant Bovine/Human Parainfluenza Virus Type 3 (B/HPIV3) expressing the Respiratory Syncytial Virus (RSV) G and F Proteins can be used to achieve simultaneous mucosal immunization a
  • 4Alexander C, Schmidt, Daniel R. Wenzke et al. Mucosal Immunization of Rhesus Monkeys against Respiratory Syncytial Virus Subgroups A and B and Human Parainfluenza Virus Type 3 by Using a Live cDNA-Derived Vaccine Based on a Host Range-Attenuated Bovine Pa
  • 5Mario H. Skiadopoulos, Sonja R. Surman, Jeffrey M. Riggs et al.A chimeric Human-Bovine parainfluenza virus type 3 expressing measles virus hemagglutinin is attenuated for replication but is still immunogenic in Rhesus Monkeys. J Virol, 2001, 75(21): 10498
  • 6Haller AA, Mitiku M, MacPhail M. Bovine parainfluenza virus type 3 (PIV3) expressing the respiratory syncytial virus (RSV) attachment and fusion proteins protects hamsters from challenge with human PIV3 and RSV. J Gen Virol,2003, 84:2153-2162.
  • 7Skiadopoulos MH, Surman SR, Riggs JM et al. Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees. Virology,2002, 297:153-160.
  • 8Newman JT, Surman SR, Riggs JM et al. Sequence analysis of the Weshington/1964 strain of human parainfluenza virus type 1 (HPIV1) and recovery and characterization of wild-type recombinant HPIV1 produced by reverse genetics. Virus Genes,2002, 24:77-92.
  • 9Skiadopoulos MH, Tatem JM, Surman SR et al. The recombinant chimeric human parainfluenza virus type 1 vaccine candidate, rHPIV3-1cp45, is attenuated, immunogenic, and protective in African green monkeys. Vaccine, 2002, 20:1846-1852.
  • 10Kelly J. Henrickson. Parainfluenza Viruses. Clinical Microbiology Reviews, 2003,16: 242-264.

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国外医学（病毒学分册）
2004年 第5期

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