摘要
通过测定取代芳烃对发光菌毒性,用Free-Wilson法和分子连接性法研究了取代芳烃结构与活性的相关性,取代基的毒性顺序为:-Br>-COOH>-NO_2≈-Cl>-CH_3>-NH_2.建立了EC_(50)与LC_(50)的相关性,并预测了一些化合物的LC_(50)值,结果和实测值符合较好.
The toxicities of substituted aromatic compounds to photobacterium phos-phoreum were studied. Relationships between structure and activity of organic compounds were examined by Free-Wilson and Molecular connectivity methods. The order of toxicity contributions for six substituents investigated is as follows. - Br>-COOH>-NO2≈-Cl>-CH3 >-NH2. The relationship between EC50 and LC50 was established. LC50 values were predicted by the EC50 values. The predicted LC50 values are close to those observed.
出处
《环境科学学报》
CAS
CSSCI
CSCD
北大核心
1993年第4期442-449,共8页
Acta Scientiae Circumstantiae
基金
国家自然科学基金资助课题
关键词
结构
活度
发光细菌
取代芳烃
毒性
Photobacterium phosphoreum
molecular connectivity
structure and activity.
