帕金森病患者工作记忆检查结果分析(英文)

Analysis of the working memory of patients with Parkinson disease

背景:工作记忆障碍是帕金森病患者最常见的认知障碍之一,但检查方法不同常常导致结果不一致。目的:比较不同方法对帕金森病患者工作记忆障碍检查的敏感性。设计:病例对照研究。地点和对象:对本院帕金森病和锥体外系疾病诊疗中心确诊的帕金森病患者(30例)进行研究,排除继发性帕金森病和帕金森综合征。正常对照组(30例)选择同年龄段健康老年人,无头痛,头晕。无神经系统阳性体征。无严重心、肺、肾脏疾病。方法:对确诊的帕金森病患者及正常对照组进行简明精神状态量表(MMSE)评分,Zung量表评分,本顿视觉保持测验及仿Smith工作记忆软件检查。主要观察指标:①本顿视觉保持测验成绩。②空间工作记忆检查正确率。③物体工作记忆检查正确率。结果:帕金森病患者与正常对照组在年龄、受教育年限、智能等方面无显著性差别。本顿视觉保持测验成绩帕金森病组犤(21.00±4.81)分犦与对照组犤(22.96±4.84)分犦比较,差异无显著性意义(t=0.0034,P>0.05)。帕金森病患者空间工作记忆成绩犤(76.95±14.4)%犦较对照组犤(91.00±6.77)%犦显著降低,差异有显著性意义(t=3.806,P<0.01)。帕金森病患者物体工作记忆成绩犤(67.06±7.95)%犦与对照组犤(72.70±8.12)%犦相比差异无显著性意义(t=0.0081,P>0.05)。结论:仿Smith工作记忆软?

BACKGROUND:The working memory dysfunction is one of the most common cognitive deficit in patients with Parkinson disease, but different results may gain by different neuropsychological assessments. OBJECTIVE:To compare the sensitivity of different neuropsychological assessment in judging the working memory deficit in patients with Parkinson disease. DESIGN:Diagnosis-based non-randomized control trial. SETTING and PARTICIPANTS:Thirty patients with clinical definite Parkinson disease were enrolled in the experiment.Those with secondary Parkinson disease and Parkinson syndrome were excluded.Thirty healthy aged peoples were selected into normal control group who were matched in age and never complaints,such as headache and dizzy,without positive neurological sign,as well as serious cardiac,lung and kidney disease. METHODS:Participants of two groups subjected to be tested by MMSE and Zung chart,Benton visual retain test and modified Smith working memory software analysis. MAIN OUTCOME MEASURES:①Benton visual retain ability;②Correct rate of spatial working memory;③Correct rate of subject working memory. RESULTS:Both groups were matched in age, education, intelligence and so on.The results of Benton visual retain test were(21.00±4.81) and(22.96±4.84) in PD group and control group respectively,the difference was unobvious(t=0.003 4,P >0.05). The correct rate of spatial working memory(76.95±14.4)%was significantly lower than that in normal controls(91.00±6.77)%(t=3.806,P< 0.01);there was no statistical difference in visual object shape working memory impairment between PD group (67.06±7.95)%and healthy controls(72.70±8.12)%(t=0.008 1,P >0.05). CONCLUSION:The result of present study proves that visual spatial working memory deficit in patients with PD is not emerged from Benton visual retain test,bud can be detected by using modified Smith working memory software,indicating modified Smith working memory software analysis is more sensitive than Benton visual retain test.