阿尔茨海默病患者红细胞电泳时间的改变(英文)

Changes of erythrocyte electrophoresis in patients with Alzheimer disease

背景:目前可用脑脊液中tau蛋白升高和Aβ蛋白降低诊断阿尔茨海默病;血液中APP,PS1和PS2基因突变诊断可用于家族性阿尔茨海默病诊断;APOEε4基因多态性分析不能作为一个诊断指标;血液中α1-抗凝乳胰蛋白酶浓度诊断阿尔茨海默病阳性率较高,但特异性差;血小板APP异构体的比例在阿尔茨海默病中有特征性分布;国际上有一个实验室观察到红细胞电泳在阿尔茨海默病中有高特异性改变,在此同时观察了阿尔茨海默病和血管性痴呆红细胞电泳时间的改变。目的:研究红细胞电泳时间与阿尔茨海默病的关系,为判断阿尔茨海默病临床检测指标的可靠性提供理论依据。设计:采用病例对照单盲临床实验的方法。地点和对象:在北京社区年龄≥60岁的人群中选择诊断为阿尔茨海默病患者11例,38例无痴呆及脑梗死病史者为对照组。干预:观察两组中红细胞电泳时间的变化,进行统计学处理。主要观察指标:红细胞电泳时间,诊断阳性率。结果:阿尔茨海默病患者红细胞电泳时间小于老年组,90%单侧下限值,即12.74s,以其为阳性界限,阿尔茨海默病、血管性痴呆和老年对照组的诊断阳性率分别为81.82%(P=0.00000123),76.92%(P=0.00001024)和7.55%。结论:红细胞电泳时间缩短与Alzheimer病相关,对于辅助诊断Alzheimer病有较好的特异性。

BACKGROUND:There was only one foreign laboratory observed the result of a high positive rate change of erythrocyte electrophoresis in Alzheimer disease. OBJECTIVE:To research the relationship between time of erythrocyte electrophoresis and Alzheimer disease as diagnostic basis for clinical assay of Alzheimer disease. DESIGN:Case controlled clinical single blind trial. SETTING and PARTICIPANTS:A total of 11 patients diagnosed as Alzheimer disease,above 60 years old among communities in Beijing, 13 patients were vascular dementia group, and 53 patients were control group without dementia and cerebral infarction. INTERVENTIONS:The change of time of erythrocyte electrophoresis in those two groups was observed,and statistical analysis was used. MAIN OUTCOME MEASURES:Time of erythrocyte electrophoresis and positive rate of diagnosis. RESULTS:Time of erythrocyte electrophoresis in Alzheimer disease patients is less than that of in aged group, with 90%single lower limit value i.e. 12.74 s,as the positive verge, the positive rates in Alzheimer disease group,vascular dementia group and aged control group were 81.82%(P=0.000 001 23 < 0.001), 76.92%(P=0.000 010 24< 0.001),and 7.55%,respectively. CONCLUSION:Shortening of time of erythrocyte electrophoresis is related to Alzheimer disease,and it is very specific for the diagnosis of Alzheimer disease.