运德素治疗慢性丙型肝炎疗效观察

The Effect of Hapgen Treatment on the Chronic Hepatitis C

目的 :探讨运德素治疗慢性丙型肝炎患者的临床疗效。方法 :治疗组患者 5 6例 ,运德素 3万U每周 3次 ,疗程 6个月 ,对照组 5 4例接受除干扰素以外的常规治疗 ,疗程亦为 6个月 ,定期检测丙氨酸氨基转移酶 (ALT)、抗丙型肝炎病毒 (HCV)、HCV RNA ,并观察药物副作用。结果 :治疗 6个月后 ,治疗组和对照组抗HCV、HCV RNA阴转分别为4 2 86 % ,5 7 1% ,0 ,1 85 % (两组比较P <0 0 1) ,治疗组治疗前后血ALT( x±s)值分别为 15 7± 37和 4 7± 2 8,治疗前后比较P <0 0 1,治疗 6个月后 ,治疗组和对照组ALT复常分别为 5 3 6 %和 4 8 1% ,两组比较P >0 0 5。结论 :运德素能抑制HCV的复制 ,降低ALT水平 ,促进HCV和HCV RNA的阴转 。

Objective: To evaluate hapgen therapy in Chroni c hepatitis C patients.Methods:Eifty six patients received hapgen 3Mu 3 times/w for 6 months,and 54 patients received current treatment except int erferon as control.The efficacy and safety were evaluated with clinical,biochemical and virological par ameters.Results:After 6 months,Hcv-Ab and Hcv-RNA negative were 42.86%,57.1%,0,and 1.85% of patients received hapgen and control treatmen t respectively (P<0.01).Before hapgen treatment and affer 6 months,serum AL T(±s)were 157±37,and 42±28(P<0.01).After 6 months,ALT normali zation(upper limit of normal) rate was 53.6% and 48.1% of patients received hapgen and control treatment(P<0.01).Conclusion: Hapgen effe ctively suppressed HCV replicaton and decreased ALT level,as well as improved HC V-Ab and HCV-RNA negative and it was safe. [