摘要
目的 探讨乳腺癌和纤维腺瘤动态增强MR对比剂空间分布及其与微血管密度 (MVD)的相关性。资料与方法 对 6 3例乳腺肿瘤术前行MR平扫和动态增强扫描 ,分析瘤中心、瘤边缘和瘤旁MR对比剂空间分布情况。术后标本行免疫组织化学染色 ,测定肿瘤MVD及分布情况 ,并分析与相应病灶MR对比剂空间分布之间的关系。结果 乳腺癌与纤维腺瘤内部MR对比剂空间分布有显著性差异 ,乳癌组瘤边缘强化程度 (△SI)显著高于瘤中心 ;而腺瘤组瘤边缘△SI显著低于或等于瘤中心。乳癌组瘤中心、瘤边缘和瘤旁△SI显著高于腺瘤组。乳腺肿瘤动态增强MR对比剂空间分布与MVD呈显著正相关。结论 乳腺癌和纤维腺瘤动态增强MR对比剂空间分布显著不同 ,并且与MVD分布密切相关。
Objective To investigate the spatial distribution of contrast agent in dynamic enhanced MR for breast benign and malignant neoplasm, to discuss its correlation with microvessel density (MVD).Materials and Methods Both plain and dynamic contrast-enhanced MR scanning was performed in 63 patients with breast neoplasm before operation. The spatial distribution of MR contrast agent at the tumor's center and periphery and also in the space around the tumor was analyzed. The removed specimens were stained with conventional hematoxylin and eosin (HE), and stained with immunohistochemistry to estimate MVD and its spatial distribution. The relationship between the spatial distribution of MR contrast agent and MVD was analyzed. Results Significant difference in the spatial distribution of MR contrast agent existed between breast cancer and breast fibroadenoma. In breast cancer, the enhancement rate (△SI) of the early-phase signal intensity at the peripheral area was significantly higher than that at the lesion's center. In breast fibroadenoma, the ?SI of the early-phase signal intensity at the peripheral area was significantly lower than, or equal to, that at the lesion's center. The △SI at the center, peripheral area and the area around the tumor was significantly higher in cancer group than that in fibroadenoma group. Obvious positive correlation existed between the spatial distribution of contrast agent and MVD. Conclusion The spatial distribution of contrast agent in dynamic enhanced MR is extremely different between breast cancer and fibroadenoma, but it correlates well with MVD.
出处
《临床放射学杂志》
CSCD
北大核心
2004年第10期857-861,共5页
Journal of Clinical Radiology
