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转化生长因子-β及基因多态性与纤维化的关系 被引量：8

Relationship of transforming growth factor β and gene polymorphism to fibrosis
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摘要 转化生长因子-β(TGF-β)是细胞生长和分化的多功能调节因子,它的功能非常复杂,在多种组织细胞的增殖分化、间质形成、组织损伤修复、骨质增生、胚胎发育及免疫抑制中起重要作用[1].它在多种纤维增生性疾病中表现出共同的促纤维化的作用.大量的体内实验已证明,TGF-β在肺纤维化的形成过程中有重要作用.本文重点就近年来TGF-β与纤维化关系的研究进展作一简要综述.
作者 李娟 范雪云
机构地区 华北煤炭医学院预防医学系
出处 《中华劳动卫生职业病杂志》 CAS CSCD 北大核心 2004年第5期382-385,共4页 Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词 纤维化 转化生长因子-Β TGF-β 基因多态性 间质 体内实验 纤维增生 增殖分化 胚胎发育 细胞生长
分类号 R363 [医药卫生—病理学]
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参考文献28

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二级参考文献18

  • 1Santana A, Saxena B, Noble NA, et al. Increased expression of transforming growth factor β isoforms(β1 ,β2 β3) in bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol, 1995,13 : 34-44.
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共引文献21

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引证文献8

二级引证文献54

中华劳动卫生职业病杂志
2004年 第5期

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