测定分配系数(K_d)方法的讨论

A Review on the Methods for Determining Partition Coefficient (K_d).

根据静态和动态实验资料讨论了影响分配系数的主要因素.认为准确测定分配系数的关键是要求实验模型对自然体系具备足够的模拟性。文中提出了测定Kd的动态模拟实验方法。研究表明。在很多情况下该法算得的Kd值接近实际,且该法具有简便、实用等优点。对某些情况,如快速反应,则分配系数可用动态模拟实验的特例——静态模拟实验来测定,同样能得到接近实际的值,且过程更为简单。

The factors affecting partition coefficient (Kd) were discussed . based on experimental data, It is considered that the key to precisely determining a partition coeffieient is to have an experimental model which is sufficiently im-itable to the natural system. An experimental method for determing Kd by dynamical simulation is suggested. The Kd values calculated with this method are close to the real values in many cases and the method is found to be simple , convenient and practical. In some cases such as quick reaction, the Kd values may be determined by using a static simulation experiment which is more simple and a special case of the dynamical simulation experiment, and the results are also close to the real situation.