遗传多态和吸烟与肺癌风险——人类疾病中基因-环境相互作用的范例
被引量:1
摘要
近10多年来,我国城乡人群的肺癌发生率呈显著而稳定上升的趋势,已成为危害最严重的恶性病之一.吸烟是肺癌确认的主要病因.在我国,50%的肺癌是吸烟引起的,与不吸烟者比较吸烟者发生肺癌的风险增加3~10倍.
出处
《医学研究通讯》
2004年第10期2-3,共2页
Bulletin of Medical Research
同被引文献10
-
1Lunn RM, Helzlsouer KJ, Parshad R, et al. XPD polymorphisms: effects on DNA repair proficiency[J]. Carcinogenesis,2000,21 ( 4 ) : 551-555.
-
2Shefl MR, Jones IM, Mohrenweiser H. Noncenservative amino acid substimtion variants exist at polymorphic frequency in DNA repair genes in healthy human[J]. Cancer Res, 1998,58 ( 4 ) : 60-66.
-
3Schaeffer L, Moncollin V, Roy R, et al. ERCC2/DNA repair protein is associated with the class II BTF2/TFIIH transcription factor[J]. EMBO J, 1994,13 ( 4 ) : 2388-2395.
-
4Brobghton BC, Steingrimsdottir H, Lehmann AR. Five polymorphisms in the coding sequence of the xeroderma pigmentosum group D gene[J]. Murat Res, 1996,362 ( 2): 209-216.
-
5Hemroinki K, Xu G, Anjni S, et al. XPD exon 10 and 23 polymorphism and DNA repair in human skin in situ[J]. Carcinogenesis,2001,22 (4): 1185- 1193.
-
6Hou SM, Falt S, Angdi S, et al. The XPD wriant alleles are associated with increased aromatic DNA adduct level and lung cancer risk[J]. Carcinogenesis, 2002,23 ( 5 ) : 599-605.
-
7Spitz MR, Wu X, Wang Y, et al. Modulation of nueleotide excision repair capacity by XPD polymorphism in lung cancer patients[J]. Cancer Res ,2001, 61 (5): 1354-1362.
-
8Popanda O, Sehattanberg T, Zaolana J, et al. Specific combinations of DNA repair gene variants and increased for non-small cell lung cancer[J]. Carcinogen,2004,25 ( 12 ): 2433-2439.
-
9Liang G, Xing D, Miao X, et al. Sequence variations in the DNA repair gene XPD and risk of lung cancer in a Chinese population[J]. Int J Cancer,2003, 105 ( 5 ) : 669-675.
-
10钟文昭,吴一龙.吸烟和肺癌的遗传易感性[J].循证医学,2009,9(4):201-205. 被引量:5
-
1刘琳,刘杰,王哲海,宋宝,郭珺.XPD基因遗传多态与晚期结直肠癌患者化疗后生存期的关系[J].山东医药,2007,47(10):62-63. 被引量:2
-
2欣宜.餐桌上的防病搭档[J].健康之路,2006(7):30-30.
-
3Will.,CL,关键.急性白血病:新技术与诊断和分类结合的范例[J].世界医学杂志,2000,4(4):61-69.
-
4美国最新一项研究结果显示钙铁摄人过多,患肺癌风险高[J].家庭用药,2006(2):47-47.
-
5范志红.苹果能让你远离医生吗[J].保健与生活,2014(1):26-26.
-
6“起床烟”患肺癌风险更大[J].中国家庭医生,2013(11):65-65.
-
7街头吸烟会增加路人罹患肺癌风险[J].食品与健康,2012(8):4-4.
-
8苏民佳.抽“起床烟”增加患肺癌风险[J].医药前沿,2013(9):57-57.
-
9抽“起床烟”会增加患肺癌风险[J].食品与健康,2013(5):4-4.
-
10新知[J].现代苏州,2013(12):11-11.