依诺沙星的热分解机理及热动力学研究

Studies of thermal decomposition mechanism and kinetics of Enoxacin

采用差示扫描量热法(DSC)、热重法(TG)和微分热重法(DTG),研究了非氧状态下药物依诺沙星的热分解动力学过程,运用Coats-Redfern方法计算了其特征热分解动力学参数-表观活化能(E)、指前因子(A)、热分解动力学方程(k)。并通过量子化学AM1方法计算的各原子对作用能,分析推断药物热解过程。

By making use of DSC, TG, and DTG, the thermal kinetic decomposition process of Enoxacin in the state of no oxygen and by Coants-Redfern, all such parameters as their activation energy, frequency factor, and kinetic equation of thermal decomposition are calculated. And by using AMI of quantum chemistry, the functional energy of each pair of atoms is calculated and the thermal decomposition of the drug is analysed.