麻风易感人群NK细胞活性的检测

Determination of the activity of NK cell in the susceptible leprous population

目的 探讨麻风病易感因素 ,为研究麻风患者细胞免疫低下与遗传因素的关系提供参考数据。 方法 采用改良细胞毒法对恩施州麻风病高发区 12 0位与麻风患者有血缘关系的人群进行NK细胞活性检测 ,并检测当地无麻风病家族史的正常健康人群NK细胞活性作为对照。 结果 大多数与麻风患者有血缘关系的人NK细胞活性与正常人没有差异 ,少数个体NK细胞活性明显低于正常人 (χ2 =4.0 7,P <0 .0 5 )二者有显著差异。 结论 NK细胞活性低下可能是麻风易感原因之一。

Objective To explore the susceptible factors leading to leprous infection and offer reference data for research on the relationship between low cytoimmunity and heredity factors in leprous patients. Methods The activity of natural killer cell from 120 persons having blood relationship with leprous patients in Enshi Prefecture, a high leprous prevalent area were assayed by using modified cytotoxicity test. Local health persons without familial leprosy history were taken as control. Results No differences were observed in activities of natural killer cells between person having blood relationship with leprous patients and the healthy persons without familial leprosy history. But the activities of natural killer cells were obviously lower than a few of healthy individuals (χ2=4.07,P<0.05). Conclusion The low activity of natural killer cells might be one of the causes susceptible to leprous infection.