N,N-二羟乙基甘氨酸的合成研究

One of Prepairation Methods of N,N-bis(2-hydroxyethyl)glycine

介绍了生物分子缓冲剂N,N-二羟乙基甘氨酸(Bicine)的一种合成方法,并对合成条件进行了优化。通过试验探索确定合成的优惠条件为:二乙醇胺与40%乙二醛水溶液摩尔比为1∶1,反应温度为95℃,反应时间2h。产品收率为82.48%。

The preparation method of N,N-bis(2-hydroxyethyl)glycine (bicine) was introduced. The optimum condition is as follows: the proportion of diethanolamine to glyoxal is 1∶1, The reaction time is 2 h and the reaction temperature is 95 ℃. The yield of bicine is up to 82.48%.