摘要
p38丝裂原活化蛋白激酶 (mitogen activatedproteinkinases ,MAPKs)作为MAPK家族的成员 ,传统认为它主要参与调控细胞应激反应和免疫反应。近年来发现它还参与调控细胞的增殖、凋亡和分化。在不同应激刺激下 ,p38MAPKs通过多条信号转导通路作用于细胞周期的各个检验点 ,抑制细胞增殖 ,阻滞细胞于不同周期。
The p38 MAPKs are members of the MAPK family. Its pathwa y has been traditionally associated with the stress and immune response. More rec ently, it has been reported that the p38 MAPKs pathway can also regulate apoptos is and some differentiation process. It can regulate cellular growth and cell c ycle checkpoints in different ways depending on the cell type and the stimulus.
出处
《生理科学进展》
CAS
CSCD
北大核心
2004年第4期315-320,共6页
Progress in Physiological Sciences
基金
中国科学院知识创新工程 (KSCX2 3 0 7 8)
国家自然科学基金 (30 2 2 80 32 )资助课题
