Caveolae/Caveolins与病毒感染

Caveolae/Caveolins and Virus Infection

Caveolae是直径为 5 0～ 10 0nm的细胞表面特异性内陷结构 ,Caveolins是它的主要标志蛋白。Caveolae/Caveolins在许多生理、病理活动中起重要作用。近年来还发现 ,Caveolae/Caveolins介导了许多病毒的感染 ,参与了病毒的吸附、穿入、转运、生物合成、组装及出泡等环节。这一病毒感染途径的发现 ,有助于抗病毒新药的开发和肿瘤治疗新领域的开辟。

Caveolae, whose major structural proteins ar e Caveolins, are classically defined as flask-shaped plasma membrane invaginati ons with a characteristic diameter of 50 to 100 nm. Caveolae/Caveolins play impo rtant roles in many physiological and pathological activities. In recent years, Caveolae/Caveolins were found to associate with the absorption, entry, trafficki ng, replication, assembly and budding for many viruses. This route helps break a new pathway to the exploitation of new antiviral drugs and the prevention and t reatment of tumors.