CpG DNA在系统性红斑狼疮发病中的作用
摘要
CpGDNA中含有的未甲基化的CpG基序是一种天然的免疫刺激剂 ,通过Toll样受体 9介导信号传导 ,诱导B细胞多克隆增殖活化 ,产生针对自身抗原的自身抗体 ,在系统性红斑狼疮发病中可能起了重要的作用。同时 ,系统性红斑狼疮患者对于CpGDNA的天然免疫反应存在缺陷。通过CpGDNA对系统性红斑狼疮致病作用的研究 。
出处
《国外医学（皮肤性病学分册）》
2004年第6期360-362,共3页
Foreign Medical Sciences(Section of Dermatology and Venereology)
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