氯硝西泮与氟哌啶醇治疗酒精所致精神障碍兴奋的对照研究

A Comparative Study of Clonazepam and Haloperidol in the Treatment of Patients with Excitement of Alcohol-caused Psychotic Disorder

目的:比较氯硝西泮与氟哌啶醇肌注治疗酒精所致精神障碍兴奋的疗效和副反应。方法:对100例符合CCMD-3酒精所致精神障碍诊断标准的兴奋患者,分别应用氯硝西泮(50例)与氟哌啶醇(50例)肌注治疗7天。用临床疗效总评量表(CGI)的病情严重程度(S1)、疗效总评(G1)和副反应量表(TESS),评定药物的疗效和副反应。结果:氯硝西泮与氟哌啶醇肌注疗效相当,而氯硝西泮起效快,副反应较氟哌啶醇轻。结论:氯硝西泮肌注治疗酒精所致精神障碍的兴奋疗效肯定,副反应轻。

Objective: To explore the efficacy and side effects of clonazepam and haloperidol in the treatment of excitement of psychotic disorder due to use of alcohol. Methods: A total of 100 patients met the criteria of CCMD-3 for alcoholic psychotic disorder were randomly assigned to clonazepam group and haloperidol group for one week treatment by injection. Efficacy and side effects were assessed by CGI and TESS. Results: Both drugs had similar efficacy, but clonazepam had less side effects and took into effect quickly. Conclusion: Clonazepam has a rapider effect and gentler side effects for the treatment of alcoholic psychotic disorder.