快速进入高原者肺功能变化及意义

The Changes of Pulmonary Function in Subjects Acute Exposed to High Altitude

目的 :了解快速进入高原者机体在高原低氧环境下肺功能改变及其意义。方法 :在 15 0名快速进入高原者中随机抽取 4 0人 ,于进藏前 1d及进藏的第 3d和第 7d分别进行肺功能检测 ,检测项目包括用力肺活量 (FVC)、一秒通气量 (FEV1.0 )、用力肺活量 /肺活量预测值 (%FVC)、一秒率(FEV1.0 % )、最大峰流速 (PF)及中期流速 (V75～V2 5 ) ,并对上述指标进行比较。结果 :快速进入高原者进入高原后肺功能各指标检测均较平原值升高 ,其中进入高原第 3d各指标变化尤为显著 ,第7d次之 (P <0 .0 5～ 0 .0 1)。结论 :快速进入高原者为适应高原缺氧环境 ,肺功能会发生由代偿到逐步习服的生理性改变 ,了解此过程 ,对于快速进入高原者AHAD的预防 ,尤其是对快速进驻高原部队合理科学的训练提供了依据。

Objective:To study the changes of lung function in healthy individuals acute exposed to high altitude. Methods: 40 individuals were selected randomly from 150 healthy persons who swiftly went to plateau but never go before. Level of FVC, FEV1.0, %FVC, FEV1.0%, PF and V 75～V 25 were compared 1 day before and 3 days, 7days after they enter to plateau.Results: The mean values of the lung function increased significantly after they were exposed to high altitude from plain (P<0.05～P<0.01), most significant change happened in the third days, then mitigated in 1 week.Conclusion: The physiological changes of lung functions will happen accordingly compensated at first as the body exposes to hypoxic environment. This finding might be helpful for prevention of AHAD, and it can as a base to established for training of army who mobilized rapidly from plain to high altitude.