Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems

Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems

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摘要 A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure. A diastereoselective method for the synthesis of chiral pyrrolidine and piperidine ring containing compounds was described. The protocol of bromination followed by aminocyclization furnishes an easily handled while highly efficient procedure for the intramolecular amidation of an isolated double bond. High diastereomeric excess was observed in this synthetic procedure.

作者邵志会彭芳芝朱保昆涂永强张洪彬

机构地区 State Key Laboratory of Applied Organic Chemistry School of Pharmacy State Key Laboratory of Applied Organic Chemistry

出处《Chinese Journal of Chemistry》 SCIE CAS CSCD 2004年第7期727-731,共5页 中国化学（英文版）

基金 Project supported by the National Natural Science Foundation of China (No. 20272049).

关键词 DIASTEREOSELECTIVE PYRROLIDINE PIPERIDINE aminocyclization diastereoselective, pyrrolidine, piperidine, aminocyclization

分类号 O626 [理学—有机化学]

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Chinese Journal of Chemistry

2004年第7期

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Diastereoselective Synthesis of Chiral Pyrrolidine and Piperidine Ring Systems

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