P物质抗血清对外周神经损伤性痛觉过敏的预防作用

Prevention of Hyperalgesia Resulted from the Sciatic Nerve Ligation by Substance P Antiserm

本文探讨耗竭脊髓背角P物质(Substance P,SP)对外周神经损伤所引起的痛觉过敏的影响,结果表明给新生大鼠皮下注射SP抗血清,成年后脊髓背角SP明显耗竭(SP含量下降48.9％)的动物对损伤坐骨神经所造成的痛觉过敏较注射正常兔血清的对照组明显减轻(P<0.05),且背角SP含量越低,痛觉过敏表现也越轻。此外,还对SP参与调节外周神经损伤性痛觉过敏的机制进行了讨论。

Subs ance P (SP) antiserum was administered subcutaneously to rats on the days 2 of life, 2 months later, the content of SP was decreased in the dorsal horn of the spinal L1-L5 by 48.9% (P<0.05) . The phenomenon of hyperalgesia was appeared significantly in the antiserum treated group compared with that of the control group. There was positive correlation between the degree of hyperalgesia and the SP content of the dorsal horn (r = 0.757, P<0.05). These results suggest that a long-lasting SP suppression may alleviate the hyperalgesia caused by the sciatic nerve ligation.