慢性阻塞性肺病患者动脉血一潮气末CO_2分压差与死腔/潮气容积比较

Arterial-end-tidal PCO_2 Difference and Dead Space/Tidal Volume Ratio in COPD Patients

对74例正常人和85例慢性阻塞性肺病患者研究了动脉血—潮气末CO_2分压差(Pa-etCO_2)和生理死腔/潮气比例(V_D/V_T)的关系。正常人和患者的潮气末CO_2分压(Pet CO_2)均与Pa CO_2密切相关(r分别为0.90和0.89,P<0.001),但患者的Pa-et CO_2较大,高达2.21kPa。正常人和患者的Pa-et CO_2均与V_D/V_T呈显著正相关(r分别为0.48和0.60,P均小于0.001)。提示Pet CO_2仅能可靠地反映正常人Pa CO_2的改变,但Pa-et CO_2却可较好地反映正常人和患者通气/血流比例的变化。

The relationship between arterial-end-tidal PCO2 difference (Pa-et CO2) and dead space/tidal volurce ratio (VD/VT) in 74 normal persons and 85 patients with chronic obstructive pulmonary disease (COPD) was studied. There was a significant correlation between end-tidal CO2 tension (pet CO2) and arterial CO2 tension (PaCO2) in normal persons (r = 0.90, p<0.001) and COPD patients (r = 0.89, P<0.001) , but the difference of Pet CO2 and PaCO2 was wider in COPD patients, which could reach to 2.21kPa. There was also a close correlation between Pa-et CO2 and VD/VT in normal persons (r=0.48, p<0.001) and COPD patients (r = 0.60, P<0.001) . It suggested that PetCO2 could only reflect the change of PaCO2 in normal persons, but Pe-et CO2 could reflect the change of ventilation/perfusion ratio bouth in normal persons and COPD patients.