摘要
番红花提取物（１００、２００ｍｇ·ｋｇ（－１），ｉｐ）可明显抑制ＩＳＯ（４ｍｇ·ｋｇ（－１），ｓｃ）所致大鼠急性实验心电图Ｊ点的位移（升高或降低）。番红花提取物（１００、２００ｍｇ·ｋｇ（－１）·ｄ（－１）×２ｄ，ｉｐ）可显著减少ＩＳ０（４ｍｇ·ｋｇ（－１）·ｄ（－１）×２ｄ，ｓｃ）所致Ｔ波双相或倒置以及Ｑ波的出现，并能明显改善ＩＳＯ所致心肌病理改变。提示番红花提取物对异丙肾上腺素诱发的心肌损伤具有良好的保护作用。
he effects of Crocus were investigated on myocardial
injury induced by isoprenaline(ISO)inrats. In acute experiments,the extracts from Crocus
(100,200 mg· kg(-1),ip)markedly inhibitedthe shift of J point in ECG caused by ISO(4 mg·
kg(-1),sc).In subacute experiments,the extractsfrom Crocus reduced the appearance frequency
of inversion or biphasic pattern of T wave and ap-pearance of Q wave caused by ISO(4 mg·
kg(-1)·d(-1)×2 d,SC)and improved the pathologicalchanges in myocardium. The extracts from
Crocus are suggested to have a protective effect on themyocardial injury caused by ISO.
出处
《南京铁道医学院学报》
1994年第3期136-139,共4页
Journal of Nanjing Railway Medical College
