摘要
将１５例外科手术切下肺癌组织和同源正常肺组织碱性磷酸酶（ＡＬＰ）进行比较。在１１例癌组织中，ＡＬＰ酶活性显著低于同源正常肺组织。其余４例，两者酶活性无差异。癌组织与同源肺组织ＡＬＰ的热稳定性，电泳行为以及对Ｌ－Ｐｈｅ和尿素抑制的敏感性，均未发现不同，但不同于胎盘ＡＬＰ。显示两者均属于组织非特异性ＡＬＰ同工酶。实验提示，肺癌中，组织非特异性ＡＬＰ活性降低。这可能系肿瘤中存在该酶的抑制剂或在基因转录水平异常所致。
lkaline
phosphatase(ALP,E.C.3、1、3、1)isoenzyme of the lung tumors from 15 surgicalbiopsies was
compared with that of normal lung tissue from the same patients. The ALP enzy-matic activity of
cancer tissue from 11 patients was significantly lower than that of the normallung tissue of
same origin. There was no significant difference between both the tissues from theother 4
cases. No difference was found in the ALP from both the tissues with regard to ther-mostability,
polyacrylamide electrophoretic migration and sensitivity to the L-phenylalanine andurea
inhibition,but the feature of ALP from lung cancer tissue and normal lung tissue differedfrom that
of placental ALP isoenzyme. A decreased enzymatic activity of tissue-unspecific alka-line
phosphatase isoenzyme was,perhaps,due to presence of inhibitor or anomaly of genetic
tran-scription.
出处
《南京铁道医学院学报》
1994年第3期140-143,共4页
Journal of Nanjing Railway Medical College
