Ⅱ型糖尿病微血管病变患者血中超氧化物歧化酶、维生素E和过氧化脂质含量变化及其意义

CHANGES IN CONTENTS OF SOD,Ve AND LPO IN TYPE II DIABETICS WITH MICROANGIOPATHY AND THEIR CLINICAL SIGNIFICANCE

作者测定了２５例糖尿病微血管病变和１２例无微血管病变患者血中ＳＯＤ－Ｔ、ＳＯＤ－Ｍｎ、ＳＯＤ－Ｃｕ·Ｚｎ、ＶＥ、ＬＰＯ的含量。结果显示，糖尿病患者血ＳＯＤ－Ｔ、ＳＯＤ－Ｍｎ、ＳＯＤ－Ｃｕ·Ｚｎ含量明显减低（Ｐ＜０．０１），ＬＰＯ明显增高（Ｐ＜０．０１），ＶＥ含量无明显变化。但微血管病变组与无微血管病变组血中ＳＯＤ和ＬＰＯ含量无明显差异。提示糖尿病微血管病变患者血中ＳＯＤ、ＬＰＯ的含量变化系糖尿病本身的变化特征，而不是糖尿病微血管病变的结果。

evels of SOD. VE and LPO were analyzed in 25 diabetics with microangiopathy and 12 cas-es without microangiopathy. The results showed that the contents of SOD-T. SOD-Cu,Zn.SOD-Mn were lowered significantly(P<0.01),LPO highered(P<0.01) VE unchanged in dia-betes. No significant difference was noted in the contents of SOD and LPO between diabetics withmicroangiopathy and those without.The changes in contents of SOD ,LPO in diabetics with mi-croangiopathy may be characteristic of diabetes mellitus and are not the results of diabetic mi-croangiopathy.